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Posts tagged syndrome
Möbius Syndrome
Dec 9th
Background
Möbius syndrome is due, in part, to loss of function of motor cranial nerves. Although von Graefe described a case of congenital facial diplegia in 1880 , the syndrome was reviewed and defined further by Paul Julius Möbius, a German neurologist, in 1888 and 1892. Because of these contributions, Möbius is now the eponym used to describe the syndrome. p
Möbius Syndrome
The definition and diagnostic criteria for Möbius syndrome vary among authors. Both von Graefe and Möbius accepted only cases with both congenital facial diplegia and bilateral abducens nerve palsies as constituting M ö bius syndrome. In 1939, Henderson broadened the definition and included cases with congenital unilateral facial palsy.
Other authors are more restrictive in attempts to eliminate conditions of a different pathogenesis being labeled as Möbius syndrome. These investigators require the presence of a congenital musculoskeletal anomaly in order to make the diagnosis. In most studies, Möbius syndrome is defined as congenital facial weakness combined with abnormal ocular abduction.
Pathophysiology
The complete pathophysiological description of Möbius syndrome remains elusive. Whether nerve, brainstem, or muscle aplasia is the primary event has not been established. Nerves that may be involved include cranial nerves (CNs) VI through XII, with general sparing of CN VIII. CN III and CN IV can be involved, but only rarely. The facial nerves (CN VII) are involved in all cases, the abducens nerves (CN VI) in a high percentage of cases (75%), and the hypoglossal nerves (CN XII) in only a minority of cases.
Numerous theories exist concerning the primary underlying pathogenesis. More >
Weirdest Diseases – Part VI – Cotord’s Syndrome
Jul 7th
Cotord’s Syndrome is when a person thinks that they have died, lost their soul, or lost a vital organ, when in fact they have lost nothing. They may even think they do not have blood.
walking corpse
This disorder has been linked to many other disorders including schizophrenia and bipolar disorder. Other than mental illness this disorder can come about when there is a problem with the persons brain, such as an injury. Some people with this disorder may feel immortal. Although this feeling is very rare among those that have Cotord’s Syndrome. They may test their own mortality by attempting suicide. So you can see that this disorder is very dangerous to the person who has it.
This disorder was named after Jules Cotard, a French neurologist. He first discovered this disorder as well as had a patient with it. He explained in a lecture that she did not believe in God or the devil and did not believe she had certain body parts. She also didn’t think that she had to eat. There are a few other cases that are documented throughout history, this one being in the 1800′s. There are a few cases more recently, such as the one in 1994. A man thought that he did not have a stomach, thus he was starving himself. There is even more recent cases in the 2000′s. More >
Weirdest Diseases – Part III – Werewolf Syndrome
Jul 1st
The Wolf Boy, Living Werewolf or Dog-Faced Boy have been fixtures of the sideshow world for centuries.
Jo-Jo, the Dog-Faced Boy is likely the most famous of the lot however cases of hypertrichosis have been reported and documented long before Jo-Jo.
Hypertrichosis is really a blanket medical term that refers to excessive body hair. It can actually be generalized, symmetrically affecting most of the torso and limbs, or localized, affecting only a small area or location. The term is, however, usually reserved to refer to very above-average amount of normal body hair that is unwanted.
Nearly all the skin of the human body – with the exception of the palms and soles of the feet – are covered with hairs or hair follicles. More >
